약재백과 상세보기
근육과 연결 조직의 질병
| 목적 | 모델 | 평가 지표 및 치료 효과 | 참고문헌 | |
|---|---|---|---|---|
| anti-rheumatoid artritis | in vivo | rat (male) | Freund's complete adjuvant (FCA)-induced adjuvant arthritis (AA) model, paw sewlling ↓, arthritis index ↓, mesenteric lymph node lymphocytes (MLNL) proliferation↑, peripheral blood lymphocytes (PBL) ↓, IL-17 and IL-6 ↓, IL-4 and TGF-β1 ↑, p-JNK expression ↓, hyperplastic lymphatic follicle ↓ | 25 |
내분비선 영양 및 순환계
| 목적 | 모델 | 평가 지표 및 치료 효과 | 참고문헌 | |
|---|---|---|---|---|
| anti-diabetes | in vivo | rat (male) | age-related insulin resistance model, fasting insulin ↓, plasma TG ↓, insulin tolerance (kITT) ↑, hepatic glycogen ↑, fatty infiltration of hepatocytes ↓, MDA ↓, hepatic relative ATP ↑, mitochondrial membrane potential ↑, ROS ↓ | 44 |
| anti-hyperlipidemia | in vivo | rat (male) | diet-induced hyperlipidemic rat model, serum triglyceride ↓, total cholesterol ↓, LDL cholesterol ↓, VLDL cholesterol ↓, fat absorption ↓, cholesterol absorption ↓, fecal excretion of fat and cholestrol ↑, pancreatic lipase activity ↓ | 31 |
| anti-metabolic syndrme | in vivo | mice (male) | spontaneously obese Type 2 diabetic TSOD mice model, body weight increase ↓, visceral and subcutaneous fat ↓, blood glucose level ↓, plasme insulin, total cholesterol ↓, ratio of HDL/total cholesterol ↑, liver total cholesterol ↓ | 23 |
눈과 그에 딸린 기관의 질병
| 목적 | 모델 | 평가 지표 및 치료 효과 | 참고문헌 | |
|---|---|---|---|---|
| anti-retinal dysfuction | in vivo | mice (male) | 8000 lx white fluorescent light-exposed retinal functional damage model, a- and b-wave amplitudes ↑, outer nuclear layer thickness ↑, number of TUNEL-positive cells in the outer nuclear layer ↓ | 47 |
소화 계통의 질병
| 목적 | 모델 | 평가 지표 및 치료 효과 | 참고문헌 | |
|---|---|---|---|---|
| anti-cholestasis | in vivo | rat | α-naphthylisothiocyanate (ANIT) -induced cholestasis model, ALT ↓, AST ↓, ALP ↓, γ-GT ↓, TBIL ↓, DBIL ↓, TBA ↓, bile flow rate ↑, bile duct epithelial edema ↓, neutrophil infiltration ↓, bile acids biosynthesis ↓ (CYP7A1, CYP8B1, and CYP27A1 expression ↓), hepatic membrane transporters NTCP ↑, BSEP↑, basolateral transporter OSTβ ↑ | 30 |
| hepatoprotection | in vivo | mice (male) | D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure model, survival rate ↑, serum ALT level ↓, histological change for inflammation and cell infiltration ↓, serum TNF-α ↓, IL-6 ↑, cleaved caspase-3 and 8 exoressions ↓, TUNEL-positive hepatic acells ↓, MDA ↓, GSH ↑, BcL-XL expression ↑, Bax expression ↓, HO-1 expression↑, Nrf2 expression ↑, p-STAT3/STAT3 relative level ↑ | 29 |
순환 계통의 질병
| 목적 | 모델 | 평가 지표 및 치료 효과 | 참고문헌 | |
|---|---|---|---|---|
| anti-hypertension, anti-thrombogenesis | in vivo | rat (male) | stroke-prone spontaneously hypertensive rats (SHRSPs) model, systolic blood pressures ↓, number of laserpulses needed to induce the formation of an occlusive thrombus ↑, 8-hydroxy-2'-deoxyguanosine(8-OHdG) in urine ↓, NO metabolites in urine ↑, vasular relaxation ↑ | 35 |
| anti-thrombosis | in vivo | mice (male) | stasis-induced venous thrombosis model, thrombus formation (mg) induced by ligation of inferior vena cava ↓ | 43 |
| in vivo | rat (male) | arteriovenous shunt (silk thread model) in rats, thrombus weight (mg)↓↑↓↑↓↑↓↑↓↑↓↑↓↑↓↑↓↑↓↑ | ||
| in vivo | mice (male) | carrageenan-induced tail thrombosis model, thrombus length (mm)↓↑↓↑↓↑↓↑↓↑↓↑↓↑↓↑↓↑↓↑ | ||
| ex vivo | rat (male) | thrombin and collagen-induce platelet aggregation (%) ↓ | ||
신경 계통의 질병
| 목적 | 모델 | 평가 지표 및 치료 효과 | 참고문헌 | |
|---|---|---|---|---|
| anti-chronic cerebral ischemia | in vivo | rat | chronic cerebral ischemia model was simulated by permanent occlusion of bilateral common carotid arteries, escape latency ↓ in Morris water maze test, apoptosis and necrosis of the cortex and hippocampus ↓, SOD ↑, NOS ↓, AchE activity ↓ | 26 |
정신적, 행동적 장애
| 목적 | 모델 | 평가 지표 및 치료 효과 | 참고문헌 | |
|---|---|---|---|---|
| anti-depressent | in vivo | mice (male) | immobility time ↓in the tail suspension test (TST), immobility time ↓ in the forced swim test (FST) | 48 |
| anti-depressive like effect | in vivo | mice | LPS-administered model, total duration of immobility ↓in forced swim test, social interaction behavior time ↑, numbers of c-Fos-positive cells ↓ in the paraventricular nucleus of the hypothalamus and central nucleus of the amygdala, iNOS, COX-2, IL-1β and IL-6 mRNA ↓ in the hypothalamus and amygdala | 52 |
| hypnotic | in vivo | human (male) | number of wakening episodes ↓ | 22 |
호흡기 계통의 질병
| 목적 | 모델 | 평가 지표 및 치료 효과 | 참고문헌 | |
|---|---|---|---|---|
| acute lung inury treatment | in vivo | mice (male) | bronchoalveolar lavage fluid (BALF) in LPS-induced acute lung injury model, number of inflammatory cells (neutrophils, macropages) ↓, TNF-α, IL-6 and IL-1β ↓, MPO activity ↓, lung tissue histological chages (areas of inflammatory infiltration, focal area of fibrosis with collapse of air alveoli and emphysematous, as well as thickening of the alveolar wall and pulmonary congestion) ↓ | 50 |
| anti-allergic asthma | in vivo | mice (female) | ovalbumin (Ova)-induced allergic airway inflammation model, Ova-specific serum IgE level ↓, eotaxin ↓, VCAM-1 ↓, IL-4 ↓, IL-5 ↓, IL-13 ↓, inflammatory cells ↓, airway inflammation score ↓, mucus score ↓, airway resistance (RI) ↓, lung compliance (Cdyn) parameters ↑ | 38 |
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