이 약재는 감나무 Diospyros kaki Thunberg(감나무과 Ebenaceae)의 잎이다. 5~8월 사이에 어린 잎을 솎아 따서 3시간 안으로 85℃ 이상의 뜨거운 물에 약 15초 동안 담그었다가 꺼내고 찬물에 1분 동안 담그었다 꺼낸 다음 바람이 잘 통하는 그늘에서 말린다.
取蠐螬蟲, 剪去兩頭, 安瘡口上, 以艾炷灸之, 七壯一易, 不過 七枚, 無不效. 《東垣》
굼벵이 양쪽 끝을 잘라서 창구(瘡口)에 놓고 쑥 기둥을 올려놓고 뜸을 뜬다. 7장 뜸을 뜨고 나서 갈아준다. 7마리를 넘지 않아 효과를 본다. 《동원》
동의보감, 雜病篇卷之八, 諸瘡, 疳瘻, 單方
Deokjae Lee, Jungeun An, Young-Un Park, Hungjium Liaw, Roger Woodgate, Jun Hong Park, Kyungjae Myung.
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PNAS
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제 114권
17호
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2017
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Many DNA repair proteins have additional functions other than their roles in DNA repair. In addition to catalyzing PCNA polyubiquitylation in response to the stalling of DNA replication, SHPRH has the additional function of facilitating rRNA transcription by localizing to the ribosomal DNA (rDNA) promoter in the nucleoli. SHPRH was recruited to the rDNA promoter using its plant homeodomain (PHD), which interacts with histone H3 when the fourth lysine of H3 is not trimethylated. SHPRH enrichment at the rDNA promoter was inhibited by cell starvation, by treatment with actinomycin D or rapamycin, or by depletion of CHD4. SHPRH also physically interacted with the RNA polymerase I complex. Taken together, we provide evidence that SHPRH functions in rRNA transcription through its interaction with histone H3 in a mammalian target of rapamycin (mTOR)-dependent manner.