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초록정보 내용
Objectives
The purpose of this study was to systematically review and meta-analyze the effectiveness of manual therapy for musculoskeletal pain in cancer survivors.
Methods
A comprehensive literature search was conducted up to February 12, 2026, across electronic databases including PubMed, EMBASE, Cochrane CENTRAL, CNKI, KoreaMed, Kmbase, and KISS. We included randomized controlled trials (RCTs) that investigated the effects of manual therapy on musculoskeletal pain in cancer survivors. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Meta-analysis was performed using R software with a random-effects model, and the certainty of evidence was evaluated using the GRADE approach.
Results
5 RCTs involving 291 participants were included from 382 identified records. Manual therapy significantly reduced pain intensity measured by Visual Analogue Scale or Numeric Rating Scale compared with controls (SMD -0.82; 95% CI -1.46 to -0.19; p<0.05), although heterogeneity was substantial (I2 = 81.7%). Subgroup analyses showed significant pain reduction in both passive and active control groups. Secondary outcomes, including quality of life (SMD -0.04; 95% CI -0.73 to 0.64), pressure pain threshold (SMD 0.37; 95% CI -0.04 to 0.78), and functional disability (SMD -0.25; 95% CI -0.54 to 0.04), were not statistically significant. Sensitivity analyses and cumulative meta-analysis confirmed the robustness and stability of the results. The overall certainty of evidence was rated as moderate due to risk of bias related to lack of blinding.
Conclusions
Manual therapy may be an effective and safe non-pharmacological intervention for alleviating musculoskeletal pain in cancer survivors. Further large-scale, methodologically rigorous RCTs are warranted to strengthen the evidence.
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