Logger Script
바로가기 및 건너띄기 링크
본문 바로가기
주메뉴 바로가기


논문 주제별검색 기관별검색

식물 약재 구성성분과 국내 약전 성분과의 비교 연구

Comparison of chemical compounds of medicinal plant materials with compounds of domestic pharmacopoeias

김상균 (한국한의학연구원) ,   이승호 ( 한국한의학연구원) ,   김안나 ( 한국한의학연구원)

식물 약재 구성성분과 국내 약전 성분과의 비교 연구 - 저널명, 기관명, ISSN, 발행일, 권호, 페이지, 조회수, ISBN 정보 안내
저널명 大韓本草學會誌  기관명 大韓本草學會 
ISSN 1229-1765  발행일 2016 
권호 제 31권 제 5호  페이지 55-62 
조회수 306  ISBN  

초록

한글초록

한글 초록 없음

영어초록

Objective :
TM-MC was constructed to provide information on the chemical compounds of medicinal plant materials which were listed in Korean, Chinese, and Japanese pharmacopoeias. The aim of this study was to compare of the chemical compounds of TM-MC with those of domestic pharmacopoeias.
Methods :
First of all, TM-MC was updated on medicinal materials and chemical compounds which were extracted from articles up to the PubMed identifier of 26 millions. After searching for medicinal plant materials with information on their major compounds in Korean pharmacopoeias, we identified that the information on medicinal materials and chemical compounds were also existed in TM-MC. Then, we figured out how much the compounds have been studied by counting the number of articles for those compounds in TM-MC.
Results :
Information on 9 medicinal materials and about 1,700 compounds was newly added to TM-MC after manually curating 645 articles. Korean pharmacopoeias contained a total of 91compounds from 53 medicinal plant materials, while TM-MC provided information on the 89 compounds from the 53 medicinal materials in Korean pharmacopoeias. The compounds stated in Korean pharmacopoeias has been much studied by comparison with other compounds of each medicinal material in TM-MC.
Conclusion :
Most of chemical compounds stated in Korean pharmacopoeias were also listed in TM-MC, excluding two compounds. Thus, we concluded that information in TM-MC is mostly consistent with that of Korean pharmacopoeias. In the future, we will periodically update TM-MC with articles added to the MEDLINE.

열기 접기

참고문헌

이 논문의 참고문헌이 16 건이 있습니다.

1. Ru J, Li P, Wang J 외 11 명, TCMSP: adatabase of systems pharmacology for drug discovery from herbal medicines, Journal of Cheminformics (2014), Vol 6, 13 ref
2. Xue R, Fang Z, Zhang M 외 3 명, TCMID:Traditional Chinese Medicine integrative database for herb molecular mechanism analysis, Nucleic Acids Research (2013), Vol 41, D1089-D1095 ref
3. Chen CY, TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico, PLoS One (2011), Vol 6-1, e15939 ref
4. Ehrman TM, Barlow DJ, Hylands PJ, Phytochemical databases of Chinese herbal constituents and bioactive plant compounds withknown target specificities, Journal of Chemical Information and Modeling (2007), Vol 47-2, 254-263 ref
5. MEDLINE (2016-06-13), https://www.nlm.nih.gov/pubs/factsheets/medline.html
6. Kim SK, Nam SJ, Jang HC 외 2 명, TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine, BMC Complementary and Alternative Medicine (2015), Vol 15, 218 ref
7. Kim S, Thiessen PA, Bolton EE 외 11 명, PubChem Substance and Compound databases, Nucleic Acids Res (2016), Vol 44(D1), D1202-D1213
8. Pence HE, Williams A, ChemSpider: An Online Chemical Information Resource, Journal of Chemical Education (2010), Vol 87-11, 1123-1124 ref
9. Ministry of Food and Drug Safety, The Korean Pharmacopoeia. Tenth Edition, Ministry of Food and Drug Safety (2014)
10. Ministry of Food and Drug Safety, The Korean Herbal Pharmacopoeia. Notification No. 2012-135, Ministry of Food and Drug Safety (2012)
11. Entrez Programming Utilities Help (2016-06-13), http://www.ncbi.nlm.nih.gov/books/NBK25500
12. Chinese Pharmacopoeia Commission, Chinese Pharmacopoeia, 2010 English edition (2010)
13. Ministry of Health, Labour and Welfare, Japanese Pharmacopoeia, Fifteenth edition, Ministry of Health, Labour and Welfare (2007)
14. McCandless M, Hatcher E, Gospodnetić O 외 1 명, Lucene in action. 2nd ed, Manning (2010)
15. PubChem Compound filtered synonyms (2016-06-13), ftp://ftp.ncbi.nlm.nih.gov/pubchem/Compound/Extras/CID-Synonym-filtered.gz
16. Ravindran PN, Pillai GS, Babu KN, Handbook of Herbs and Spices. Peter KV eds, Volume 2, Woodhead Publishing Limited (2004), 90

열기 접기